Fluoxetine in the treatment of generalized anxiety
People who suffer from generalized anxiety disorder often resort to various treatments to try to eliminate the condition. One option is the use of psychotropic drugs, which include, in particular, fluoxetine, known commercially as Prozac. Is this drug effective in treating anxiety? What are the results? Here's an article where you can read more about it.
Among clinical forms of anxiety, generalized anxiety disorder (GAD) is the most common in primary care. Many clinical practice guidelines recommend using selective serotonin reuptake inhibitors (SSRIs) or pregabalin for treatment.
The meta-analysis included double-blind randomized clinical trials, as well as reviews and meta-analyses of randomized clinical trials. The included studies analyzed both drugs with approved indications for GAD treatment (duloxetine, escitalopram, paroxetine, pregabalin, and venlafaxine) and drugs without these indications (fluoxetine, lorazepam, sertraline, and tiagabine). Studies with reference drugs such as classical antidepressants (tricyclic clomipramine and heterocyclic maprotiline) or MAOIs were not included.
The analysis ranked the drugs analyzed for each of the following variables: response and remission (efficacy score) and attrition due to side effects (safety score). Response was defined as the proportion of patients with at least a 50% reduction on the Hamilton Anxiety Scale, and remission was defined as the proportion of patients with a final score of 7 or less on the same scale.
Fluoxetine ranked first in both drug response and symptom remission. However, this was confirmed by a single study of. Sertraline was the drug with the lowest dropout rate, and lorazepam ranked last in this ranking.
However, neither fluoxetine nor sertraline have been shown to be effective in preventing relapses. It should also be noted that most of the studies included in the review were funded by the pharmaceutical industry, had short-term follow-up, and excluded patients with significant comorbidities (including depression and other anxiety disorders). In addition, as mentioned above, reference medications such as classical antidepressants and MAOIs were not included.
For many people, medication proves to be the solution to treating generalized anxiety. However, it should be remembered that the relapse rate after substance abuse treatment is much higher than in cases where cognitive-behavioral psychotherapy was used. On the other hand, psychopharmacological treatment should always be monitored by a psychiatrist who will indicate the correct prescription and completion of treatment.